Journal article
Integrating Graphene Oxide-Hydrogels and Electrical Stimulation for Controlled Neurotrophic Factor Encapsulation: A Promising Approach for Efficient Nerve Tissue Regeneration
Alexandre Xavier Mendes, Lilith Caballero Aguilar, Adriana Teixeira do Nascimento, Serena Duchi, Mirren Charnley, David R Nisbet, Anita F Quigley, Robert MI Kapsa, Saimon Moraes Silva, Simon E Moulton
ACS Applied Bio Materials | American Chemical Society | Published : 2024
Abstract
Nerve growth factor (NGF) plays a crucial role in cellular growth and neurodifferentiation. To achieve significant neuronal regeneration and repair using in vitro NGF delivery, spatiotemporal control that follows the natural neuronal processes must be developed. Notably, a challenge hindering this is the uncontrolled burst release from the growth factor delivery systems. The rapid depletion of NGF reduces treatment efficacy, leading to poor cellular response. To address this, we developed a highly controllable system using graphene oxygen (GO) and GelMA hydrogels modulated by electrical stimulation. Our system showed superior control over the release kinetics, reducing the burst up 30-fold. ..
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Grants
Awarded by ARC Centre of Excellence for Electromaterials Science (ACES)
Awarded by Australian Research Council
Funding Acknowledgements
This work was supported by the ARC Centre of Excellence for Electromaterials Science (ACES) and the Aikenhead Centre for Medical Discovery - St Vincent's Hospital. D.R.N. gratefully acknowledges the support of the Australian Research Council for a Future Fellowship (FT230100220).